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Principal Scientist, Analytical Sciences
Korro BioRNA editing company
Cambridge, United StatesSenior
Venrock Healthcare Capital Partners
ADAR1 Capital Management
Affinity Asset Advisors
Balyasny Asset Management
Driehaus Capital Management
Kalehua Capital
About the role
TL;DR
Develop and optimize analytical methods for synthetic oligonucleotide-based therapies.
- •Korro Bio is seeking an experienced analytical scientist to join the growing CMC team.
- •You will focus on management of CMO analytical labs as well as development of analytical methods, characterization of impurities, degradation pathways, and transfer, qualification/validation of analytical methods for synthetic oligonucleotide-based therapies.
- •Key Responsibilities Serve as SME for synthetic oligonucleotide-based drug substance and drug product release and characterization assays.
- •Develop and optimize analytical methods as needed.
- •Support analytical method validation, transfer, and troubleshooting to ensure compliance with cGMP standards.
- •Collaborate with the Process/Formulation Development teams to ensure seamless integration of analytical methods into DS and DP manufacturing workflows.
- •Requirements PhD in Analytical, Organic Chemistry, or related field with 3+ years’ experience; or MS with 7+ years or BS with 10+ years of relevant industry experience. 3+ years of hands-on experience in analytical method development for small molecule therapeutics.
- •Experience in synthetic oligonucleotide therapeutics is desired.
- •Expertise in chromatographic (e.g., LC -UV, and LC-MS) and spectroscopic techniques (e.g., UV-Vis), with a strong understanding of method validation requirements.
Domain expertise
biotech