Scientist/ Senior Scientist - Translational Cardiac Biology
Until LabsOrgan Cryopreservation company
Bay AreaSenior
Founders Fund
Lux Capital
Field Ventures
Age 1
Day One Ventures
About the role
TL;DR
Develop and characterize new technologies for organ-scale reversible cryopreservation.
- •Join Until Labs to develop perfusion systems, cryoprotectant formulations, and vitrification and rewarming hardware for organ-scale reversible cryopreservation.
- •Key Responsibilities Develop clinically translatable healthy in vitro models using primary/immortalized cardiac cells, including iPSC-derived cardiomyocytes Design and implement high throughput screening (HTS) experiments to characterize the viability and functional performance of cardiac cells using MEA, calcium imaging, impedance-based readouts Create and validate complex in vitro 3D cardiac models (e.g., organoids, engineered heart tissues, micro-tissues) to accurately assess cardiotoxicity and permeability of new cryoprotectant solutions Develop innovative approaches to characterize cardiotoxicity of new compounds and their interactions with healthy heart function, including functional endpoints such as contractility, electrophysiology, and calcium handling Apply plate-reader, flow cytometry based and/or genomics techniques such as GWAS, RNAseq, and FISH to inform and refine molecular discovery and in vitro models Collaborate closely with cross-functional teams to translate experimental findings into new cryoprotectant solutions for human-sized organ preservation Recruit and mentor team members and take on greater responsibility for experimental design and strategy as needed Requirements PhD and/or Postdoc training in Cardiac Physiology, Bioengineering, Chemical Engineering, Tissue Engineering, Pharmacology, Toxicology or a related field, or have an equivalent (4+ years) of industry experience leading research projects end-to-end Have a track record of scientific excellence and autonomy, with the ability to independently develop and carry out complex experiments in cardiac biology or a related therapeutic area Hands-on expertise in cell-based assay development, including experience with primary cells, iPSC-derived cell types, or 3D in vitro models Proven ability to design and execute high throughput screening workflows and analyze multiparametric datasets Bring a collaborative mindset and value diverse perspectives Thrive fast-paced environments with high sense of mission and urgency
Domain expertise
biotech
Benefits & perks
Opportunity for outsized impact creating the future as an early team member, Generous medical, dental, and vision insurance coverage for employees and their dependents, Flexible time off and paid holidays, Competitive compensation package, including salary and equity, Access to a 401(k) retirement savings plan, FSA and commuter benefits, Subsidized lunch daily