Senior Scientist, Cardiac Preservation (Organ Perfusion)
Until LabsOrgan Cryopreservation company
Bay AreaSenior
Founders Fund
Lux Capital
Field Ventures
Age 1
Day One Ventures
About the role
TL;DR
Lead heart preservation efforts within the whole organ preservation team.
- •We are seeking a Senior Scientist, Cardiac Preservation to lead our heart preservation efforts within the whole organ preservation team.
- •Key Responsibilities Develop and execute ex vivo heart perfusion protocols, including normothermic machine perfusion (NMP), to maintain and evaluate cardiac viability before and after cryopreservation.
- •Build out the heart viability assessment toolkit, including contractile and hemodynamic function, perfusion metrics, metabolic and lactate profiling, histology, and omics.
- •Propose and test adjustments to cryoprotectant formulations, loading/unloading, cooling, and rewarming protocols to optimize cardiac health and recovery.
- •Translate detailed knowledge of cardiac physiology and biology into experimental design and interpretation across the team.
- •Requirements Deep, hands-on expertise in ex vivo heart perfusion, ideally including normothermic machine perfusion (NMP) of the heart.
- •Intimate understanding of cardiac physiology and biology, including myocardial metabolism, contractile function, and ischemia/reperfusion injury.
- •Experience designing and running organ viability assessments and interpreting multimodal readouts (functional, metabolic, histological, omics).
- •Comfort working at the bench in an ex vivo model and a track record of executing complex experimental protocols.
- •Demonstrated success working through hard, open-ended problems, with a passion for rapid problem solving and rapid exploration of unfamiliar topics and protocols.
- •Ability to think from first principles and tackle complex, cross-disciplinary problems alongside other scientists and engineers.
Domain expertise
biotech