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Senior Platform Engineer

Orchestra.bioOrchestra.bio is a
San Francisco, United StatesSenior
Software Engineering

About the role

TL;DR

Build and maintain foundational infrastructure for an intelligent R&D management platform.

  • •About Orchestra Orchestra helps companies navigate the journey from discovery to medicine by connecting science, operations, and finance in an intelligent platform.
  • •We're on a mission to make every R&D dollar count.
  • •Developing new medicines is a societal imperative to improve human health and reduce medical costs.
  • •Brilliant science needs effective management to develop breakthrough medicines that reach patients.
  • •We aim to bring the same level of sophistication to scientific development that modern tools brought to software development.
  • •While software teams can ship updates daily, R&D organizations face unique challenges: years long development cycles, complex interdependencies, and high-stakes decisions that can make or break billion dollar programs.
  • •Founded by early Benchling leaders, we just emerged from stealth with $20M in funding from 8VC, Andreessen Horowitz, Insight Partners, Definition, and Haystack to transform how biotech companies operate.
  • •Our customers are working on society's most important challenges, including neurodegeneration, cancer, metabolic disease, and biomanufacturing.
  • •We're looking for engineers who are excited about building software that helps scientific organizations operate more effectively.
  • •The Role We're seeking a Senior Platform Engineer to join our growing team in San Francisco.
  • •You'll build and maintain the foundational infrastructure that powers Orchestra's intelligent R&D management platform, ensuring our systems can scale reliably as we help more companies bring breakthrough innovations to market.
  • •Challenges You'll Tackle Mission Critical Infrastructure: Design and maintain the cloud infrastructure that biotech companies depend on for managing billion dollar R&D programs.
  • •Build systems that handle sensitive scientific data, complex financial modeling, and AI workloads with the reliability and security these high stakes operations demand.
  • •Scalable AI Operations: Create the platform infrastructure that powers our AI driven signals extraction from meeting transcripts, documents, and operational data.
  • •Design systems that can process unstructured data at scale while maintaining performance and cost efficiency as our customer base grows.
  • •Developer Experience: Create tooling and infrastructure that enables our engineering team to ship features rapidly and reliably.
  • •Design CI/CD pipelines, monitoring systems, and development environments that help us maintain quality while moving at startup speed.
  • •Security & Compliance: Implement infrastructure that meets the stringent requirements of biotech and pharmaceutical companies.
  • •Build towards SOC 2 compliance while maintaining the development velocity needed in a fast-growing startup environment.
  • •What Sets You Apart Complexity: You understand how to build platform infrastructure for complex, data-intensive applications where reliability directly impacts scientific outcomes.
  • •You're excited about the technical challenges of supporting AI workloads, financial modeling, and secure data processing at scale.
  • •Curiosity: You're genuinely curious about how breakthrough products are developed and excited about building infrastructure that helps scientific organizations operate more effectively.
  • •You want your platform work to contribute to bringing medicines and other innovations to market.
  • •Agency: You're drawn to environments where you can shape both the technical infrastructure and operational practices.
  • •You enjoy the responsibility of building foundational systems that will scale, balancing the speed needed at an early stage company with the reliability required for mission critical software.
  • •Qualifications Required 5+ years of platform/infrastructure engineering or SRE experience Strong expertise in cloud infrastructure (AWS/GCP/Azure) including IaC tools (Terraform, CloudFormation) Hands-on experience with monitoring and observability, implementing and running alerting systems and incident response Hands-on experience with CI/CD pipeline design, implementation and maintenance Collaborative mindset with proven track record of working effectively in small, fast-moving engineering teams Preferred SOC 2 compliance implementation experience: security controls, monitoring, audit preparation Performance optimization experience for data intensive applications AI-assisted development proficiency; leveraging tools to accelerate infrastructure work
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Required skills

TerraformCloudFormationAWSGoogle CloudAzureCI/CDDockerKubernetesPythonBashSOC 2

Nice-to-have skills

PrometheusGrafanaDatadogNew RelicPagerDuty

Domain expertise

biotechdeeptech

Tech stack

AWSGoogle CloudAzureTerraformCloudFormationDockerKubernetesCI/CDGitHub ActionsJenkinsArgoCDHelmGitLab CICircleCIAnsibleChefPuppetPrometheusGrafanaDatadogNew RelicPagerDutyNginxHAProxyPythonJavaScriptTypeScriptBash

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