Research Scientist II/Senior, Computational Chemistry
Iambic TherapeuticsAI Drug company
San Diego, United StatesSenior
Coatue
NVIDIA
Abingworth
Exor
Illumina Ventures
Mubadala Capital
Data & AI
About the role
TL;DR
Computational Chemist to drive drug discovery using advanced SBDD techniques.
- •Iambic Therapeutics is seeking a skilled Computational Chemist to drive drug discovery efforts using advanced ligand and structure-based techniques.
- •You will collaborate with ML scientists, medicinal chemists, and biologists to apply SBDD methods across various drug discovery phases.
- •Key Responsibilities Apply ligand and structure-based approaches across hit identification, hit to lead, and lead optimization phases.
- •Guide design cycles by identifying structure-activity relationships and integrating computational predictions with bioactivity data.
- •Partner with medicinal chemists to design, evaluate, and prioritize virtual libraries.
- •Integrate SBDD methods with proprietary transformer-based property prediction technology.
- •Leverage and evolve proprietary protein-ligand co-folding technology to yield novel structural hypotheses.
- •Requirements PhD or equivalent degree in computational chemistry (or related field) with 2+ years of relevant experience in drug discovery.
- •Experience supporting active small molecule drug discovery programs.
- •Experience with ligand and structure based design tools.
- •Proficiency in Python for scientific computing, data analysis, and computational workflow development.
- •Excellent written and verbal communication skills.
Required skills
Python
Domain expertise
biotechhealthcare
Benefits & perks
company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, uncapped vacation, onsite gym, onsite dining
Tech stack
Python